Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 5.562


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7



Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_122722674 16.265 NM_005328
HAS2
hyaluronan synthase 2
chr11_+_101488380 15.511 NM_001195045
YAP1
Yes-associated protein 1
chr7_-_41709191 13.504 NM_002192
INHBA
inhibin, beta A
chr3_-_55489973 12.003 WNT5A
wingless-type MMTV integration site family, member 5A
chr7_-_27171600 11.305 HOXA9
homeobox A9
chr3_+_174598937 10.646 NM_014932
NLGN1
neuroligin 1
chr7_-_27171648 10.373 HOXA9
homeobox A9
chr7_-_27171673 10.238 NM_152739
HOXA9
homeobox A9
chr1_+_168898898 9.820 PRRX1
paired related homeobox 1
chr13_-_101852028 9.377 NM_175929
FGF14
fibroblast growth factor 14
chr5_+_174084137 9.293 NM_002449
MSX2
msh homeobox 2
chr7_+_113842284 8.921 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr1_-_20682541 8.233


chr7_-_27149750 8.217 NM_019102
HOXA5
homeobox A5
chr7_-_27108826 8.100 NM_006735
HOXA2
homeobox A2
chr9_+_117955890 8.038 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr12_+_88268845 7.591 LOC100131490
hypothetical LOC100131490
chr7_+_113842470 7.533 FOXP2
forkhead box P2
chr7_+_113842407 7.487 FOXP2
forkhead box P2
chr14_+_51025604 7.410 NM_001042481
FRMD6
FERM domain containing 6
chr9_-_116920232 7.205 NM_002160
TNC
tenascin C
chr5_+_59819761 7.142 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr9_+_108665168 6.782 NM_021224
ZNF462
zinc finger protein 462
chr10_-_33663305 6.723 NRP1
neuropilin 1
chr2_-_164300758 6.676 NM_018086
FIGN
fidgetin
chr6_+_12825818 6.572 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr10_+_24795446 6.552 KIAA1217
KIAA1217
chrX_+_28515479 6.519 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr2_-_160764819 6.493 NM_000888
ITGB6
integrin, beta 6
chr10_+_24795465 6.382 KIAA1217
KIAA1217
chr20_+_19903778 6.337 RIN2
Ras and Rab interactor 2
chr3_-_115960807 6.319 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr7_-_83662152 6.192 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr9_-_8723893 6.054 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr22_-_34566210 5.952 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_+_66516196 5.914 MEIS1
Meis homeobox 1
chr16_-_49742651 5.762 NM_002968
SALL1
sal-like 1 (Drosophila)
chr7_+_134114912 5.608 CALD1
caldesmon 1
chr3_-_115825742 5.607 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr22_-_34566276 5.581 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr5_-_59819642 5.577 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_134226727 5.516 CALD1
caldesmon 1
chr22_-_34566367 5.509 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr10_+_52420936 5.503 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr3_-_150578148 5.501 TM4SF1
transmembrane 4 L six family member 1
chr12_-_88270128 5.445 DUSP6
dual specificity phosphatase 6
chr21_-_34820916 5.440 NM_203418
RCAN1
regulator of calcineurin 1
chr3_-_150578103 5.429 TM4SF1
transmembrane 4 L six family member 1
chr3_-_150578207 5.372 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr18_+_30544193 5.364 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr5_+_155686333 5.311 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr13_+_34948977 5.307 NBEA
neurobeachin
chr8_-_72431274 5.299 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr6_+_136214495 5.255 NM_018945
PDE7B
phosphodiesterase 7B
chr10_-_92671005 5.238 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr21_-_38792173 5.218 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr13_+_34948885 5.146 NBEA
neurobeachin
chr3_+_158637273 5.129 NM_002852
PTX3
pentraxin 3, long
chr4_-_87989291 5.046 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr6_-_138935359 5.034 NM_020464
NHSL1
NHS-like 1
chr10_-_118887801 5.007 NM_001112704
NM_199131
VAX1

ventral anterior homeobox 1

chr3_-_21767819 4.964 NM_024697
ZNF385D
zinc finger protein 385D
chr14_-_94306104 4.964 NM_173849
GSC
goosecoid homeobox
chr4_+_119174947 4.935 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr6_-_152744022 4.861 SYNE1
spectrin repeat containing, nuclear envelope 1
chr4_-_23500706 4.843 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr12_-_90100733 4.831 NM_001920
DCN
decorin
chr1_+_81544432 4.798 LPHN2
latrophilin 2
chr9_+_674193 4.795


chr2_-_190635566 4.786 NM_005259
MSTN
myostatin
chr14_+_85069217 4.783


chr8_+_70541631 4.746 SULF1
sulfatase 1
chr12_-_88270369 4.727 DUSP6
dual specificity phosphatase 6
chr13_+_100902942 4.665 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_-_200033445 4.652 SATB2
SATB homeobox 2
chr13_-_37070862 4.643 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr13_-_85271329 4.598 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr5_-_59100194 4.583 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_+_102380156 4.545 NM_001018116
MURC
muscle-related coiled-coil protein
chr2_-_189752575 4.542 NM_000393
COL5A2
collagen, type V, alpha 2
chr21_-_38955487 4.533 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr5_+_36642424 4.526 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_-_128567302 4.505 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr20_-_14266200 4.495 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr12_-_88270375 4.494 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr8_+_77756077 4.447 ZFHX4
zinc finger homeobox 4
chr10_+_69539255 4.435 NM_032578
MYPN
myopalladin
chr5_-_1935764 4.429 NM_016358
IRX4
iroquois homeobox 4
chr2_-_160765008 4.387 ITGB6
integrin, beta 6
chr17_-_36346240 4.358 KRT23
keratin 23 (histone deacetylase inducible)
chr13_-_45323757 4.331 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr7_+_134114957 4.318 CALD1
caldesmon 1
chr3_-_62334229 4.291 NM_018008
FEZF2
FEZ family zinc finger 2
chr4_+_54790020 4.281 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr6_+_21701942 4.279 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr5_-_59100091 4.275 PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_116488458 4.274 NM_002031
FRK
fyn-related kinase
chr6_-_138862273 4.243


chr14_-_91483325 4.242 FBLN5
fibulin 5
chr12_-_89922875 4.239 EPYC
epiphycan
chr20_-_49852353 4.228 NM_020436
SALL4
sal-like 4 (Drosophila)
chr18_+_30427279 4.128 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr11_+_131285747 4.111 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr8_+_70541412 4.091 NM_001128204
NM_015170
SULF1

sulfatase 1

chr20_+_31613800 4.084 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr14_-_53493198 4.082 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chrX_+_85404626 4.057 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr4_+_183302105 4.052 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr15_-_53996597 4.040 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr3_-_64647325 4.004 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr1_+_213245507 3.992 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr2_-_151052391 3.989 NM_005168
RND3
Rho family GTPase 3
chr5_+_152850276 3.981 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr15_+_55298908 3.933 NM_207040
TCF12
transcription factor 12
chr13_-_34948758 3.906 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chrX_-_19598912 3.905 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr18_+_59705918 3.902 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr7_+_134114701 3.898 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr12_-_89922888 3.888 NM_004950
EPYC
epiphycan
chr16_+_7322751 3.887 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr8_+_77756061 3.880 NM_024721
ZFHX4
zinc finger homeobox 4
chr3_+_116824840 3.867 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr6_-_169395972 3.865 NM_003247
THBS2
thrombospondin 2
chr12_-_16650697 3.852 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_150578023 3.850 TM4SF1
transmembrane 4 L six family member 1
chr12_-_90100710 3.848 DCN
decorin
chr5_-_124108672 3.813 NM_020747
ZNF608
zinc finger protein 608
chr3_-_79899748 3.798 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr12_-_16650687 3.792 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_90100679 3.787 DCN
decorin
chr2_+_211166323 3.775 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr2_+_210152609 3.773 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr3_-_64186151 3.691 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr12_-_14024187 3.650 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chrX_-_138552517 3.638 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr6_+_121798443 3.638 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr10_+_52421120 3.628 PRKG1
protein kinase, cGMP-dependent, type I
chr4_+_81325447 3.604 NM_020226
PRDM8
PR domain containing 8
chr10_-_29963906 3.591 NM_021738
SVIL
supervillin
chr16_+_85169615 3.565 NM_005250
FOXL1
forkhead box L1
chr7_-_96471544 3.553 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr6_+_12825022 3.523 PHACTR1
phosphatase and actin regulator 1
chr12_-_88269884 3.509 DUSP6
dual specificity phosphatase 6
chr5_+_36642213 3.501 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr9_-_94226380 3.478 NM_005014
OMD
osteomodulin
chr5_+_127012611 3.472 NM_001048252
CTXN3
cortexin 3
chr2_+_210152399 3.446 MAP2
microtubule-associated protein 2
chr2_+_33213111 3.426 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr8_-_49996353 3.403 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chrX_-_33267646 3.401 NM_000109
DMD
dystrophin
chr12_+_118100977 3.388 NM_014365
HSPB8
heat shock 22kDa protein 8
chrX_+_135058402 3.385 NM_001159700
FHL1
four and a half LIM domains 1
chr8_-_15140162 3.368 NM_139167
SGCZ
sarcoglycan, zeta
chrX_+_77889861 3.364 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr4_-_110443247 3.354 NM_032518
NM_198721
COL25A1

collagen, type XXV, alpha 1

chrX_-_64112993 3.321 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr3_+_190990142 3.308 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr3_-_11585264 3.295 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr9_+_27099138 3.294 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr11_-_85107569 3.289 NM_206929
SYTL2
synaptotagmin-like 2
chr2_-_45090025 3.276 NM_016932
SIX2
SIX homeobox 2
chrX_-_33139349 3.274 NM_004006
DMD
dystrophin
chr4_-_152366970 3.272 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr3_+_25445071 3.268 RARB
retinoic acid receptor, beta
chr4_+_41309482 3.261 LIMCH1
LIM and calponin homology domains 1
chr7_+_134226690 3.257 NM_033139
NM_033140
CALD1

caldesmon 1

chr5_-_111119846 3.249 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr18_-_39111243 3.246 NM_020783
SYT4
synaptotagmin IV
chr12_-_85756766 3.227 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr3_+_89239494 3.206 EPHA3
EPH receptor A3
chr9_-_72673753 3.205 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr4_+_54790190 3.204 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_-_127810087 3.190 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chrX_+_135106578 3.174 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr7_-_27120015 3.170 HOXA3
homeobox A3
chr8_-_6407882 3.163 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr11_-_40272239 3.147 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr4_-_159312973 3.145 FAM198B
family with sequence similarity 198, member B
chr20_+_11846536 3.134 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr9_-_20612433 3.116 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_-_133145539 3.107 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr3_-_116272911 3.106 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr10_-_92670764 3.081 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_41579325 3.076


chr2_+_36777336 3.068 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr18_+_64616296 3.055 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr15_-_31147376 3.052 NM_001103184
FMN1
formin 1
chr6_-_56615544 3.046 NM_001723
NM_015548
DST

dystonin

chr12_+_79625538 3.038 NM_002469
MYF6
myogenic factor 6 (herculin)
chr1_-_214963279 3.023 NM_001438
ESRRG
estrogen-related receptor gamma
chr9_-_20612476 3.000 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_+_137224266 2.996 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr3_-_55490401 2.993 WNT5A
wingless-type MMTV integration site family, member 5A
chr5_+_66160359 2.963 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_+_234490781 2.960 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr7_-_27162688 2.944 NM_006896
HOXA7
homeobox A7
chr3_-_115380539 2.940 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr11_-_85103438 2.925 NM_032379
SYTL2
synaptotagmin-like 2
chr8_-_87824996 2.899 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr12_-_15757114 2.865 EPS8
epidermal growth factor receptor pathway substrate 8

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 1.60e-36 GO:0032501 multicellular organismal process
1.46 1.39e-28 GO:0048731 system development
1.41 1.50e-28 GO:0007275 multicellular organismal development
1.43 2.73e-28 GO:0048856 anatomical structure development
1.37 1.73e-26 GO:0032502 developmental process
1.56 6.31e-19 GO:0007399 nervous system development
1.51 4.54e-16 GO:0009653 anatomical structure morphogenesis
1.42 2.67e-14 GO:0048513 organ development
1.61 6.83e-13 GO:0022008 neurogenesis
1.62 1.74e-12 GO:0048699 generation of neurons
1.38 4.31e-12 GO:0030154 cell differentiation
1.41 5.48e-12 GO:0003008 system process
1.36 1.47e-11 GO:0048869 cellular developmental process
1.65 8.51e-11 GO:0030182 neuron differentiation
1.57 2.82e-10 GO:0009888 tissue development
1.16 2.03e-09 GO:0050896 response to stimulus
1.51 9.24e-09 GO:0048468 cell development
1.48 1.58e-08 GO:0009605 response to external stimulus
1.55 4.01e-08 GO:2000026 regulation of multicellular organismal development
1.68 4.65e-08 GO:0000904 cell morphogenesis involved in differentiation
1.39 5.22e-08 GO:0050877 neurological system process
1.49 9.47e-08 GO:0050793 regulation of developmental process
1.91 1.00e-07 GO:0061061 muscle structure development
1.62 1.43e-07 GO:0048666 neuron development
2.25 1.53e-07 GO:0045165 cell fate commitment
1.46 1.54e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.60 2.28e-07 GO:0009887 organ morphogenesis
1.82 4.61e-07 GO:0001501 skeletal system development
1.49 5.27e-07 GO:0007600 sensory perception
1.95 5.29e-07 GO:0003002 regionalization
1.54 1.14e-06 GO:0045595 regulation of cell differentiation
1.67 2.12e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.57 2.15e-06 GO:0000902 cell morphogenesis
1.50 2.23e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.62 2.63e-06 GO:0031175 neuron projection development
1.67 2.93e-06 GO:0007409 axonogenesis
2.20 3.55e-06 GO:0007156 homophilic cell adhesion
1.49 3.60e-06 GO:0007155 cell adhesion
1.49 3.60e-06 GO:0022610 biological adhesion
1.65 3.65e-06 GO:0048812 neuron projection morphogenesis
1.51 3.98e-06 GO:0009790 embryo development
1.54 4.72e-06 GO:0032989 cellular component morphogenesis
1.54 5.68e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.53 8.20e-06 GO:0030030 cell projection organization
2.08 8.27e-06 GO:0009952 anterior/posterior pattern formation
1.50 1.21e-05 GO:0010628 positive regulation of gene expression
1.58 1.33e-05 GO:0007417 central nervous system development
1.96 1.39e-05 GO:0007517 muscle organ development
1.59 2.29e-05 GO:0007606 sensory perception of chemical stimulus
1.71 2.79e-05 GO:0007411 axon guidance
1.43 2.90e-05 GO:0009891 positive regulation of biosynthetic process
1.35 3.05e-05 GO:0051239 regulation of multicellular organismal process
1.70 3.52e-05 GO:0007389 pattern specification process
1.59 3.76e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.18 4.00e-05 GO:0014706 striated muscle tissue development
1.57 4.10e-05 GO:0048858 cell projection morphogenesis
1.43 4.74e-05 GO:0031328 positive regulation of cellular biosynthetic process
2.12 5.28e-05 GO:0060537 muscle tissue development
1.79 5.40e-05 GO:0045596 negative regulation of cell differentiation
1.40 5.61e-05 GO:0042127 regulation of cell proliferation
1.55 7.50e-05 GO:0032990 cell part morphogenesis
1.44 8.43e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.45 8.89e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.70 9.65e-05 GO:0060284 regulation of cell development
2.03 1.01e-04 GO:0043062 extracellular structure organization
1.18 1.39e-04 GO:0023052 signaling
2.41 1.40e-04 GO:0048706 embryonic skeletal system development
1.47 1.50e-04 GO:0051254 positive regulation of RNA metabolic process
1.70 1.61e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.37 1.92e-04 GO:0007154 cell communication
1.40 2.11e-04 GO:0040011 locomotion
1.58 2.36e-04 GO:0032583 regulation of gene-specific transcription
2.47 2.52e-04 GO:2000027 regulation of organ morphogenesis
2.58 2.73e-04 GO:0007519 skeletal muscle tissue development
1.67 2.94e-04 GO:0051093 negative regulation of developmental process
1.55 3.47e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.62 3.62e-04 GO:0048598 embryonic morphogenesis
2.50 4.26e-04 GO:0060538 skeletal muscle organ development
1.57 4.54e-04 GO:0007608 sensory perception of smell
1.24 5.06e-04 GO:0048523 negative regulation of cellular process
1.42 5.61e-04 GO:0007267 cell-cell signaling
1.85 6.38e-04 GO:0048732 gland development
1.50 7.44e-04 GO:0008284 positive regulation of cell proliferation
1.99 8.83e-04 GO:0050678 regulation of epithelial cell proliferation
1.66 9.70e-04 GO:0016337 cell-cell adhesion
1.54 1.06e-03 GO:0051094 positive regulation of developmental process
1.22 1.24e-03 GO:0048519 negative regulation of biological process
2.36 1.44e-03 GO:0022612 gland morphogenesis
1.59 1.60e-03 GO:0007420 brain development
1.20 1.81e-03 GO:0048518 positive regulation of biological process
1.67 1.90e-03 GO:0007423 sensory organ development
2.63 1.92e-03 GO:0070848 response to growth factor stimulus
1.63 1.97e-03 GO:0009991 response to extracellular stimulus
1.67 2.23e-03 GO:0048545 response to steroid hormone stimulus
1.42 2.74e-03 GO:0009719 response to endogenous stimulus
1.64 2.75e-03 GO:0031667 response to nutrient levels
1.78 3.65e-03 GO:0007584 response to nutrient
1.54 3.70e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
3.51 3.82e-03 GO:0002053 positive regulation of mesenchymal cell proliferation
1.36 3.93e-03 GO:0006351 transcription, DNA-dependent
1.17 4.46e-03 GO:0007165 signal transduction
1.46 4.70e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.56 4.80e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.20 4.86e-03 GO:0048522 positive regulation of cellular process
1.10 5.14e-03 GO:0050794 regulation of cellular process
1.88 8.27e-03 GO:0001655 urogenital system development
1.54 8.53e-03 GO:0009792 embryo development ending in birth or egg hatching
1.54 8.68e-03 GO:0043009 chordate embryonic development
1.94 8.73e-03 GO:0001763 morphogenesis of a branching structure
1.44 9.42e-03 GO:0051253 negative regulation of RNA metabolic process
1.09 9.77e-03 GO:0050789 regulation of biological process
1.45 1.01e-02 GO:0006935 chemotaxis
1.45 1.01e-02 GO:0042330 taxis
1.29 1.20e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.83 1.21e-02 GO:0048562 embryonic organ morphogenesis
1.28 1.48e-02 GO:0009893 positive regulation of metabolic process
1.41 1.49e-02 GO:0009725 response to hormone stimulus
1.94 1.56e-02 GO:0033273 response to vitamin
3.22 1.96e-02 GO:0010464 regulation of mesenchymal cell proliferation
1.46 2.00e-02 GO:0072358 cardiovascular system development
1.46 2.00e-02 GO:0072359 circulatory system development
2.80 2.04e-02 GO:0071363 cellular response to growth factor stimulus
1.09 2.21e-02 GO:0065007 biological regulation
1.58 2.36e-02 GO:0048729 tissue morphogenesis
1.88 2.41e-02 GO:0042692 muscle cell differentiation
2.35 2.78e-02 GO:0050680 negative regulation of epithelial cell proliferation
1.54 2.87e-02 GO:0045597 positive regulation of cell differentiation
1.59 2.89e-02 GO:0035295 tube development
1.59 2.89e-02 GO:0051960 regulation of nervous system development
1.27 3.21e-02 GO:0031325 positive regulation of cellular metabolic process
1.94 3.29e-02 GO:0043583 ear development
1.38 3.39e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.13 3.42e-02 GO:0051716 cellular response to stimulus
2.31 4.11e-02 GO:0048704 embryonic skeletal system morphogenesis
1.66 4.81e-02 GO:0043193 positive regulation of gene-specific transcription
2.95 4.83e-02 GO:0060688 regulation of morphogenesis of a branching structure
1.61 4.90e-02 GO:0050767 regulation of neurogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 9.78e-12 GO:0005886 plasma membrane
1.22 3.44e-11 GO:0071944 cell periphery
1.88 1.46e-09 GO:0005578 proteinaceous extracellular matrix
1.80 1.47e-09 GO:0031012 extracellular matrix
1.31 2.10e-09 GO:0005576 extracellular region
1.43 3.71e-08 GO:0044421 extracellular region part
2.09 7.67e-05 GO:0030016 myofibril
1.22 1.61e-04 GO:0044459 plasma membrane part
2.01 2.17e-04 GO:0043292 contractile fiber
1.42 6.57e-04 GO:0030054 cell junction
1.36 6.91e-04 GO:0005615 extracellular space
2.01 7.02e-04 GO:0044449 contractile fiber part
1.96 1.88e-03 GO:0044420 extracellular matrix part
1.48 4.33e-03 GO:0043005 neuron projection
1.91 8.67e-03 GO:0030055 cell-substrate junction
1.72 9.64e-03 GO:0070161 anchoring junction
1.95 1.09e-02 GO:0030017 sarcomere
1.29 1.75e-02 GO:0042995 cell projection
1.44 1.78e-02 GO:0045202 synapse
1.73 1.87e-02 GO:0005912 adherens junction
1.58 2.06e-02 GO:0016323 basolateral plasma membrane
2.58 2.13e-02 GO:0005581 collagen
1.21 3.79e-02 GO:0005856 cytoskeleton
4.51 3.99e-02 GO:0005614 interstitial matrix
1.83 4.82e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.65 1.70e-11 GO:0005509 calcium ion binding
1.60 6.05e-10 GO:0043565 sequence-specific DNA binding
1.48 1.18e-09 GO:0001071 nucleic acid binding transcription factor activity
1.48 1.18e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.40 2.82e-06 GO:0030528 transcription regulator activity
1.62 2.23e-05 GO:0004984 olfactory receptor activity
1.40 7.45e-05 GO:0004930 G-protein coupled receptor activity
1.34 1.93e-04 GO:0005102 receptor binding
1.30 2.37e-04 GO:0004888 transmembrane receptor activity
1.25 6.00e-04 GO:0004872 receptor activity
1.22 9.11e-04 GO:0004871 signal transducer activity
1.22 9.11e-04 GO:0060089 molecular transducer activity
1.58 1.04e-03 GO:0003779 actin binding
1.82 2.18e-03 GO:0008083 growth factor activity
1.68 5.59e-03 GO:0000975 regulatory region DNA binding
1.68 5.59e-03 GO:0001067 regulatory region nucleic acid binding
1.68 5.59e-03 GO:0044212 transcription regulatory region DNA binding
2.39 7.17e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.43 7.68e-03 GO:0003707 steroid hormone receptor activity
1.67 1.12e-02 GO:0010843 promoter binding
2.29 2.55e-02 GO:0042562 hormone binding
1.38 3.13e-02 GO:0008092 cytoskeletal protein binding